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| Game | Favorite | Line | Underdog | Bowl | Date | TV Time (EST) |
| Game1 | Southern Mississippi (SOM) | -17 | Arkansas State (ARS) | New Orleans | 12/20/2005 | ESPN 8:00 p.m. |
| Game2 | Toledo (TOL) | -2.5 | UTEP (UTP) | GMAC | 12/21/2005 | ESPN 8:00 p.m. |
| Game3 | California (CAL) | -6.5 | BYU (BYU) | Las Vegas | 12/22/2005 | ESPN 8:00 p.m. |
| Game4 | Navy (NAV) | -2.5 | Colorado State (CSU) | Poinsetta | 12/22/2005 | ESPN2 10:30 p.m |
| Game5 | Kansas (KAN) | -3 | Houston (HOU) | Fort Worth | 12/23/2005 | ESPN 8:00 p.m. |
| Game6 | Nevada (NEV) | -2 | Central Florida (CFL) | Hawaii | 12/24/2005 | ESPN 8:30 p.m. |
| Game7 | Memphis (MEM) | -5.5 | Akron (AKR) | Motor City | 12/26/2005 | ESPN 4:00 p.m. |
| Game8 | Clemson (CLE) | -2 | Colorado (COL) | Champs Sports | 12/27/2005 | ESPN 5:00 p.m. |
| Game9 | Arizona State (ASU) | -11.5 | Rutgers (RUT) | Insight | 12/27/2005 | ESPN 8:30 p.m. |
| Game10 | Boise State (BSU) | -1.5 | Boston College (BOS) | MPC Computers | 12/28/2005 | ESPN 4:30 p.m. |
| Game11 | Michigan (MIC) | -12 | Nebraska (NEB) | Alamo | 12/28/2005 | ESPN 8:00 p.m. |
| Game12 | Georgia Tech (GTK) | -8.5 | Utah (UTA) | Emerald | 12/29/2005 | ESPN 4:30 p.m. |
| Game13 | Oregon (ORU) | -3 | Oklahoma (OKA) | Holiday | 12/29/2005 | ESPN 8:00 p.m. |
| Game14 | Minnesota (MIN) | -3.5 | Virginia (VIR) | Music City | 12/30/2005 | ESPN 12:00 p.m. |
| Game15 | UCLA (UCL) | -3.5 | Northwestern (NWS) | Sun | 12/30/2005 | CBS 2:00 p.m. |
| Game16 | South Carolina (SCL) | -4.5 | Missouri (MIZ) | Independence | 12/30/2005 | ESPN 3:30 p.m. |
| Game17 | Miami, FL (MIF) | -2.5 | LSU (LSU) | Peach | 12/30/2005 | ESPN 7:30 p.m. |
| Game18 | NC State (NCS) | -6 | South Florida (SFL) | Meineke | 12/31/2005 | ESNP2 11:00 a.m. |
| Game19 | Fresno State (FSU) | -7 | Tulsa (TLS) | Liberty | 12/31/2005 | ESPN 1:00 p.m. |
| Game20 | TCU (TCU) | -4 | Iowa State (ISU) | Houston | 12/31/2005 | ESPN2 2:30 p.m. |
| Game21 | Texas Tech (TEK) | -3 | Alabama (ALA) | Cotton | 1/2/2006 | FOX 11:00 a.m. |
| Game22 | Florida (FLA) | -3 | Iowa (IOW) | Outback | 1/2/2006 | ESPN 11:00 a.m. |
| Game23 | Virginia Tech (VTK) | -8 | Louisville (LOU) | Gator | 1/2/2006 | NBC 12:30 p.m. |
| Game24 | Auburn (AUB) | -11 | Wisconsin (WIS) | Capital One | 1/2/2006 | ABC 1:00 p.m. |
| Game25 | Ohio State (OSU) | -4 | Notre Dame (NDM) | Fiesta | 1/2/2006 | ABC 4:30 p.m. |
| Game26 | Georgia (GEO) | -8 | West Virginia (WVU) | Sugar | 1/2/2006 | ABC 8:30 p.m. |
| Game 27 | Penn State (PSU) | -8 | Florida State (FSU) | Orange | 1/3/2006 | ABC 8:00 p.m. |
| Game 28 | USC (USC) | -7 | Texas (TEX) | Rose | 1/4/2006 | ABC 8:00 p.m. |